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. 2021 Dec 14;9:783088. doi: 10.3389/fcell.2021.783088

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Copyright © 2021 Lai, Quan, Hao, Liu, Wang, Dai, Dai, He and Tang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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miR-195-5p targets to PFKFB4 in HCC. (A) Heatmap of the differentially expressed genes after miR-195-5p overexpressed in SNU-449 cells (B) Volcano plot showing the significantly expressed genes. (C) KEGG analysis was used to screen the enriched pathways after miR-195-5p overexpressed. (D) Binding sites of miR-195-5p and PFKFB4 was predicted by using the ENCORI. (E) The target relationship of miR-195-5p and PFKFB4 were verified by dual-luciferase assay. (F) Influence of miR-195-5p mimics on the PFKFB4 level in SNU-449 cells. (G) Influence of miR-195-5p on LINC01572-induced upregulation of PFKFB4. All data are shown as mean ± standard deviation (n = 3). ^* p < 0.05, ^** p < 0.01.