Table 1.
Baseline characteristics by ejection fraction and IDFerritin status
| HFpEF | HFrEF | Total cohort | ||||
|---|---|---|---|---|---|---|
| n = 448 | N = 1115 | N = 1563 | ||||
| IDFerritin | Not IDFerritin | IDFerritin | Not IDFerritin | IDFerritin | Not IDFerritin | |
| n = 258 | n = 190 | n = 642 | n = 473 | n = 900 | n = 663 | |
| Age, years | 74 (11) | 70 (11) | 63 (13) | 63 (14) | 66 (13) | 65 (13) |
| Female, n (%) | 143 (55) | 72 (38) | 154 (24) | 66 (14) | 297 (33) | 138 (21) |
| BMI, kg/m2 | 30 (8) | 29 (6) | 28 (7) | 28 (7) | 28 (7) | 28 (7) |
| AF/flutter, n (%) | 154 (60) | 86 (45) | 222 (35) | 180 (38) | 376 (42) | 266 (40) |
| DM, n (%) | 114 (44) | 80 (42) | 315 (49) | 174 (37) | 429 (48) | 254 (38) |
| HTN, n (%) | 206 (80) | 134 (71) | 427 (67) | 282 (60) | 633 (70) | 416 (63) |
| PUD, n (%) | 26 (10) | 11 (6) | 36 (6) | 17 (4) | 62 (7) | 28 (4) |
| NYHA III/IV, n (%) | 81 (31) | 36 (19) | 181 (28) | 126 (27) | 262 (29) | 162 (24) |
| Hx HF hosp < 6/12, n (%) | 50 (19) | 42 (22) | 221 (34) | 136 (29) | 271 (30) | 178 (27) |
| HR, b.p.m. | 70 (60, 80) | 68 (61, 78) | 76 (67, 86) | 74 (65, 83) | 75 (64, 84) | 72 (64, 81) |
| SBP, mmHg | 129 (115, 140) | 129 (110, 142) | 118 (104, 130) | 118 (105, 132) | 120 (107, 135) | 120 (108, 136) |
| DBP, mmHg | 70 (60, 78) | 70 (61, 80) | 70 (60, 79) | 70 (62, 80) | 70 (60, 79) | 70 (62, 80) |
| NT‐proBNP, pg/mL | 1453 (710, 2693) | 969 (375, 2376) | 2513 (1342, 5057) | 1756 (824, 3932) | 2203 (1054, 4264) | 1599 (606, 3597) |
| hsTnT, ng/L | 26 (16, 44) | 23 (13, 40) | 33 (20, 52) | 26 (16, 45) | 30 (19, 50) | 25 (15, 43) |
| LVEF (%) | 61 (7) | 60 (6) | 29 (9) | 30 (9) | 38 (17) | 38 (16) |
| E:E′ | 15 (8) | 13 (7) | 18 (8) | 17 (8) | 17 (8) | 16 (8) |
| Creatinine, μmol/L | 106 (84, 138) | 109 (84, 143) | 107 (88, 136) | 104 (87, 128) | 107 (87, 137) | 105 (86, 135) |
| eGFR, mL/min/1.73 m2 | 54 (40, 69) | 57 (40, 76) | 60 (45, 77) | 64 (48, 80) | 59 (44, 75) | 62 (46, 79) |
| Hb, g/dL | 121 (18) | 129 (22) | 131 (19) | 139 (19) | 128 (19) | 136 (21) |
| HCT | 0.38 (0.06) | 0.4 (0.06) | 0.4 (0.06) | 0.42 (0.06) | 0.4 (0.06) | 0.41 (0.06) |
| Ferritin, mcg/L | 78 (47, 126) | 310 (188, 459) | 85 (51, 139) | 315 (189, 461) | 81 (49, 136) | 313 (189, 460) |
| Iron, mg/L | 10 (5) | 14 (6) | 10 (5) | 16 (8) | 10 (5) | 16 (7) |
| % saturation | 15 (7) | 25 (9) | 15 (8) | 27 (13) | 15 (7) | 27 (12) |
| Anaemia, n (%) | 144 (56) | 74 (39) | 251 (39) | 119 (25) | 395 (44) | 193 (29) |
| Anti‐coag use, n (%) | 92 (36) | 57 (30) | 174 (27) | 131 (28) | 266 (30) | 188 (28) |
| Anti‐plt use, n (%) | 121 (47) | 63 (33) | 255 (40) | 192 (41) | 376 (42) | 255 (38) |
| Iron supp, n (%) | 54 (21) | 39 (21) | 158 (25) | 141 (30) | 212 (24) | 180 (27) |
AF, atrial fibrillation; BMI, body mass index; BP, blood pressure; coag, coagulant; DBP, diastolic blood pressure; DM, diabetes mellitus; E:E′, mitral Doppler early velocity/mitral annular early velocity; eGFR, estimated glomerular filtration rate; Hb, haemoglobin; HCT, haematocrit; HR, heart rate; hsTnT, high‐sensitivity troponin T; HTN, hypertension; Hx HF hosp, history of heart failure hospitalization; ID, iron deficiency; LVEF, left ventricular ejection fraction; NYHA, New York Heart Association functional class; plt, platelet; PUD, peptic ulcer disease; sat, saturation; SBP, systolic blood pressure; supp, supplement.
Values are mean (standard deviation) or median (25% and 75% quartiles).