Table 2.
Multivariable associations with outcome [hazard ratio (95% confidence interval)]
| HFpEF | HFrEF | Total cohort | |
|---|---|---|---|
| N = 448 | N = 1115 | N = 1563 | |
| Hazard ratio for all‐cause mortality (age/gender) | |||
| IDFerritin | 0.65 (0.40–1.05) | 1.41 (1.07–1.86) | 1.21 (0.95–1.53) |
| Age | 1.09 (1.06–1.12) | 1.04 (1.03–1.05) | 1.04 (1.03–1.05) |
| Gender (F:M) | 0.83 (0.52–1.34) | 0.59 (0.40–0.86) | 0.59 (0.45–0.78) |
| IDTsat | 1.16 (0.72–1.87) | 2.31 (1.71–3.11) | 1.95 (1.52–2.5) |
| Age | 1.08 (1.05–1.11) | 1.04 (1.03–1.06) | 1.04 (1.03–1.05) |
| Gender (F:M) | 0.77 (0.48–1.23) | 0.58 (0.4–0.84) | 0.57 (0.43–0.75) |
| Hazard ratio for all‐cause mortality (all independent variables) | |||
| IDFerritin | 0.68 (0.41–1.12) | 1.12 (0.85–1.48) | 1.00 (0.78–1.27) |
| Age | 1.06 (1.03–1.11) | 1.02 (1.01–1.03) | 1.03 (1.02–1.04) |
| Gender (F:M) | 0.82 (0.49–1.40) | 0.75 (0.51–1.11) | 0.84 (0.62–1.12) |
| Ischaemic aetiology | 1.13 (0.69–1.86) | 1.82 (1.32–2.52) | 1.47 (1.13–1.90) |
| Log_NT‐proBNP | 1.80 (1.39–2.32) | 1.68 (1.45–1.93) | 1.69 (1.50–1.89) |
| NYHA | 1.47 (0.89–2.41) | 1.71 (1.29–2.26) | 1.69 (1.33–2.15) |
| SBP 10 mmHg | 0.90 (0.80–1.01) | 0.86 (0.80–0.93) | 0.88 (0.82–0.93) |
| AF | 0.75 (0.44–1.28) | 1.30 (0.97–1.74) | 1.11 (0.86–1.43) |
| logCreatinine | 1.22 (0.62–2.38) | 1.33 (0.88–2.0) | 1.36 (0.96–1.92) |
| IDTsat | 1.12 (0.69–1.84) | 1.57 (1.15–2.14) | 1.46 (1.12–1.89) |
| Age | 1.06 (1.03–1.09) | 1.02 (1.01–1.03) | 1.03 (1.02–1.04) |
| Gender (F:M) | 0.77 (0.46–1.29) | 0.74 (0.50–1.10) | 0.81 (0.6–1.08) |
| Ischaemic aetiology | 1.05 (0.65–1.71) | 1.78 (1.29–2.49) | 1.45 (1.12–1.88) |
| Log_NT‐proBNP | 1.82 (1.40–2.36) | 1.61 (1.40–1.86) | 1.65 (1.46–1.84) |
| NYHA | 1.47 (0.89–2.41) | 1.64 (1.24–2.18) | 1.65 (1.29–2.10) |
| SBP 10 mmHg | 0.89 (0.80–1.00) | 0.86 (0.80–0.93) | 0.88 (0.83–0.93) |
| AF | 0.70 (0.41–1.18) | 1.31 (0.98–1.76) | 1.12 (0.87–1.45) |
| logCreatinine | 1.22 (0.62–2.40) | 1.36 (0.90–2.06) | 1.37 (0.97–1.94) |
| Hazard ratio for death or HF hospitalization (age/gender) | |||
| IDFerritin | 1.11 (0.81–1.52) | 1.33 (1.11–1.60) | 1.29 (1.11–1.51) |
| Age | 1.03 (1.01–1.04) | 1.02 (1.01–1.03) | 1.01 (1.01–1.02) |
| Gender (F:M) | 0.90 (0.66–1.23) | 0.67 (0.53–0.85) | 0.69 (0.58–0.83) |
| IDTsat | 1.19 (0.87–1.63) | 1.66 (1.38–1.99) | 1.54 (1.31–1.80) |
| Age | 1.03 (1.01–1.04) | 1.02 (1.01–1.02) | 1.01 (1.01–1.02) |
| Gender (F:M) | 0.89 (0.65–1.22) | 0.68 (0.53–0.86) | 0.69 (0.57–0.82) |
| Hazard ratio for death or HF hospitalization (all independent variables) | |||
| IDFerritin | 0.99 (0.71–1.37) | 1.11 (0.92–1.33) | 1.07 (0.92–1.26) |
| Age | 1.00 (0.99–1.02) | 1.00 (0.99–1.01) | 1.00 (0.99–1.01) |
| Gender (F:M) | 0.97 (0.69–1.37) | 0.82 (0.64–1.05) | 0.89 (0.74–1.08) |
| Ischaemic aetiology | 1.33 (0.96–1.84) | 1.52 (1.24–1.86) | 1.44 (1.22–1.71) |
| Log_NT‐proBNP | 1.56 (1.33–1.83) | 1.37 (1.25–1.50) | 1.41 (1.31–1.51) |
| NYHA | 1.39 (1.00–1.95) | 1.54 (1.27–1.86) | 1.50 (1.27–1.77) |
| SBP 10 mmHg | 0.94 (0.87–1.01) | 0.96 (0.92–1.01) | 0.96 (0.93–1.00) |
| AF | 0.97 (0.69–1.38) | 1.04 (0.85–1.27) | 1.03 (0.87–1.22) |
| logCreatinine | 1.37 (0.89–2.10) | 1.41 (1.09–1.83) | 1.42 (1.15–1.77) |
| IDTsat | 1.06 (0.77–1.46) | 1.24 (1.02–1.50) | 1.19 (1.01–1.41) |
| Age | 1.00 (0.99–1.02) | 1.00 (0.99–1.01) | 1.00 (1.00–1.01) |
| Gender (F:M) | 0.96 (0.69–1.35) | 0.82 (0.64–1.05) | 0.89 (0.74–1.08) |
| Ischaemic aetiology | 1.32 (0.96–1.82) | 1.50 (1.23–1.84) | 1.44 (1.21–1.70) |
| Log_NT‐proBNP | 1.56 (1.33–1.82) | 1.35 (1.23–1.48) | 1.39 (1.29–1.50) |
| NYHA | 1.39 (1.00–1.95) | 1.51 (1.25–1.84) | 1.49 (1.26–1.75) |
| SBP 10 mmHg | 0.94 (0.87–1.01) | 0.96 (0.92–1.01) | 0.96 (0.93–0.99) |
| AF | 0.97 (0.69–1.37) | 1.04 (0.85–1.26) | 1.04 (0.87–1.23) |
| logCreatinine | 1.37 (0.90–2.10) | 1.43 (1.10–1.85) | 1.43 (1.15–1.77) |
AF, atrial fibrillation; Hb, haemoglobin; HF, heart failure; HFpEF, heart failure with preserved ejection fraction; HFrEF, heart failure with reduced ejection fraction; ID, iron deficiency; NYHA, New York Heart Association functional class; SBP, systolic blood pressure; Δ, change.
Bold highlights the results for iron status—the focus of the article.