Table 3.
Association of change in IDTsat status over 6 months with outcome
| BL | 6/12 | Model 1 | Model 2 (Model 1 + EF) | Model 3 (Model 2 + age + gender) | Model 4 (age + gender + ΔlogCreat + ΔHb + ΔlogNT‐proBNP) | |
|---|---|---|---|---|---|---|
| HR (95% CI) | HR (95% CI) | HR (95% CI) | HR (95% CI) | |||
| Hazard ratio for all‐cause mortality | ||||||
| ID [reference] | No | No | ||||
| ID | No | Yes | 0.84 (0.41–1.72) | 0.85 (0.42–1.74) | 0.91 (0.44–1.86) | 0.82 (0.37–1.83) |
| ID | Yes | No | 1.21 (0.72–2.03) | 1.20 (0.72–2.01) | 1.38 (0.82–2.31) | 0.99 (0.52–1.88) |
| ID | Yes | Yes | 2.22 (1.42–3.46) | 2.26 (1.45–3.53) | 2.34 (1.50–3.67) | 2.16 (1.33–3.51) |
| HFrEF | 1.22 (0.82–1.81) | 1.52 (0.99–2.31) | ||||
| Age (years) | 1.05 (1.03–1.07) | 1.06 (1.04–1.08) | ||||
| Female | 0.51 (0.32–0.82) | 0.49 (0.30–0.81) | ||||
| ΔHb (g/dL) | 1.01 (0.99–1.02) | |||||
| ΔlogCreatinine (μmol/L) | 1.74 (0.81–3.72) | |||||
| ΔlogNT‐proBNP (pg/mL) | 1.34 (1.14–1.57) | |||||
| Hazard ratio for death or HF hospitalization | ||||||
| ID [reference] | No | No | ||||
| ID | No | Yes | 1.12 (0.78–1.61) | 1.13 (0.79–1.62) | 1.16 (0.81–1.66) | 1.11 (0.73–1.69) |
| ID | Yes | No | 1.4 (1.06–1.86) | 1.38 (1.04–1.83) | 1.43 (1.08–1.90) | 1.46 (1.04–2.06) |
| ID | Yes | Yes | 1.94 (1.49–2.51) | 1.99 (1.53–2.59) | 2.04 (1.57–2.65) | 1.75 (1.30–2.37) |
| HFrEF | 1.28 (1.02–1.61) | 1.29 (1.01–1.64) | ||||
| Age (years) | 1.01 (1.00–1.02) | 1.01 (1.00–1.02) | ||||
| Female | 0.67 (0.52–0.86) | 0.63 (0.47–0.84) | ||||
| ΔHb (g/dL) | 1.01 (1.00–1.02) | |||||
| ΔlogCreatinine (μmol/L) | 2.21 (1.36–3.61) | |||||
| ΔlogNT‐proBNP (pg/mL) | 1.47 (1.34–1.62) | |||||
BL, baseline; CI, confidence interval; EF, ejection fraction; Hb, haemoglobin; HF, heart failure; HFrEF, heart failure with reduced ejection fraction; HR, hazard ratio; ID, iron deficiency; NT‐proBNP, N‐terminal pro‐brain natriuretic peptide; Δ, change.
Reference group is NN (baseline no ID, 6/12 no ID).