TABLE 3.

Influence of Clinicopathological and Genetic Alterations on OS (N = 412, 287 events)

Characteristic	HR	95% CI	P
Disease extent
Solitary liver tumor	Ref
Multifocal liver disease	1.16	0.71–1.88	0.60
Metastatic disease	2.13	1.39–3.24	<0.001
Resected	2.60	1.81–3.73	<0.001
ECOG PS
0	Ref
1	1.33	0.98–1.79	0.07
2–3	3.28	1.65–6.53	<0.001
Log CA19-9	1.06	1.00–1.12	0.05
CDKN2Adel	2.50	1.65–3.78	<0.001
TP53mut	1.87	1.31–2.68	<0.001
KRASmut	1.94	1.25–3.01	0.003

Bold indicates significance.