TABLE 3.
Influence of Clinicopathological and Genetic Alterations on OS (N = 412, 287 events)
| Characteristic | HR | 95% CI | P |
|---|---|---|---|
| Disease extent | |||
| Solitary liver tumor | Ref | ||
| Multifocal liver disease | 1.16 | 0.71–1.88 | 0.60 |
| Metastatic disease | 2.13 | 1.39–3.24 | <0.001 |
| Resected | 2.60 | 1.81–3.73 | <0.001 |
| ECOG PS | |||
| 0 | Ref | ||
| 1 | 1.33 | 0.98–1.79 | 0.07 |
| 2–3 | 3.28 | 1.65–6.53 | <0.001 |
| Log CA19-9 | 1.06 | 1.00–1.12 | 0.05 |
| CDKN2Adel | 2.50 | 1.65–3.78 | <0.001 |
| TP53mut | 1.87 | 1.31–2.68 | <0.001 |
| KRASmut | 1.94 | 1.25–3.01 | 0.003 |
Bold indicates significance.