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. 2021 Dec 13;12:730892. doi: 10.3389/fmicb.2021.730892

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Copyright © 2021 Kim, Larrous, Varet, Legendre, Feige, Dumas, Matsas, Kouroupi, Grailhe and Bourhy.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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DEG heatmaps of RABV-associated KEGG pathways and the connection to the neuronal function. (A) The relevant KEGG subset was crosschecked with DEGs from 24 hpi Tha dataset, highlighting multiple pathways that are important to cell cycle, differentiation, signal transduction, and immune response among others. (B) DEGs involved in NF-kB signaling (hsa04064) and the expression level indicated in log₂-fold changes. The time-points of significant selection were marked with black dot. Examples of DEGs and their association with neuronal function-GO terms are underlined at the base of figure. (C) DEGs detected in TNF signaling (hsa04668). (D) DEGs in IL-17 signaling (hsa04657). (E) DEGs detected in MAPK signaling (hsa04010). DEGs validated in RT-qPCR for their expression at 40 hpi (displayed on Figure 4) are marked in bold font.