1. Outcomes reported in studies but not considered in review.

Study ID	Outcomes
Burke 1996	Bronchial wall biopsy inflammatory cell profiles (detected immunohistochemically)
Gauvreau 1996	Sputum eosinophil count
Heuck 1997	Serum carboxy‐terminal propetide of type 1 collagen (PICP) Serum carboxy‐terminal pyridinioline cross‐liked telopeptide of type 1 collagen (ICTP) Serum amino‐terminal propeptide of type III procollagen (PIIINP) Urinary concentration pyridinoline crosslinks(PYD) Urinary concentration deoxypyridinoline crosslinks (DPD) Serum insulin‐like growth factor I (IGF‐I) Serum insulin‐like growth factor binding protein‐3 (IGFBP‐3)
Jatakanon 1998	Sputum eosinophil count Sputum eosinophil cationic protein Sputum tumour necrosis factor alpha Exhaled air nitric oxide concentration
Kharitonov 1996	Exhaled air nitric oxide concentration
Osterman 1997	Serum myeloperoxidase Serum neutrophil chemotactic activity Serum eosinophil chemotactic activity
Tan 1998	Serum neutrophil chemotactic activity Thoracic gas volume