1 FEV1 (% predicted) |
8 |
217 |
Mean Difference (IV, Fixed, 95% CI) |
‐3.70 [‐7.09, ‐0.31] |
1.1 400 mcg/day or less |
3 |
71 |
Mean Difference (IV, Fixed, 95% CI) |
‐2.09 [‐7.33, 3.16] |
1.2 500‐800 mcg/day |
5 |
146 |
Mean Difference (IV, Fixed, 95% CI) |
‐4.86 [‐9.31, ‐0.42] |
1.3 1000 mcg/day or greater |
0 |
0 |
Mean Difference (IV, Fixed, 95% CI) |
0.0 [0.0, 0.0] |
2 FEV1 (litres) |
4 |
103 |
Mean Difference (IV, Fixed, 95% CI) |
0.07 [‐0.25, 0.40] |
2.1 400 mcg/day or less |
0 |
0 |
Mean Difference (IV, Fixed, 95% CI) |
0.0 [0.0, 0.0] |
2.2 500‐800 mcg/day |
2 |
47 |
Mean Difference (IV, Fixed, 95% CI) |
0.14 [‐0.27, 0.55] |
2.3 1000 mcg/day or greater |
2 |
56 |
Mean Difference (IV, Fixed, 95% CI) |
‐0.04 [‐0.57, 0.49] |
3 Change in FEV1 (litres) compared to baseline |
2 |
99 |
Mean Difference (IV, Fixed, 95% CI) |
‐0.20 [‐0.33, ‐0.07] |
3.1 400 mcg/day or less |
2 |
99 |
Mean Difference (IV, Fixed, 95% CI) |
‐0.20 [‐0.33, ‐0.07] |
3.2 500‐800 mcg/day |
0 |
0 |
Mean Difference (IV, Fixed, 95% CI) |
0.0 [0.0, 0.0] |
3.3 1000 mcg/day or greater |
0 |
0 |
Mean Difference (IV, Fixed, 95% CI) |
0.0 [0.0, 0.0] |
4 Morning PEFR (L/min) |
3 |
94 |
Mean Difference (IV, Fixed, 95% CI) |
‐30.86 [‐66.51, 4.79] |
4.1 400 mcg/day or less |
1 |
17 |
Mean Difference (IV, Fixed, 95% CI) |
‐29.46 [‐107.88, 48.96] |
4.2 500‐800 mcg/day |
2 |
77 |
Mean Difference (IV, Fixed, 95% CI) |
‐31.22 [‐71.25, 8.80] |
4.3 1000 mcg/day or greater |
0 |
0 |
Mean Difference (IV, Fixed, 95% CI) |
0.0 [0.0, 0.0] |
5 Change in morning PEFR (L/min) compared to baseline |
6 |
469 |
Mean Difference (IV, Fixed, 95% CI) |
‐28.92 [‐36.11, ‐21.74] |
5.1 400 mcg/day or less |
4 |
404 |
Mean Difference (IV, Fixed, 95% CI) |
‐26.91 [‐34.42, ‐19.41] |
5.2 500‐800 mcg/day |
2 |
65 |
Mean Difference (IV, Fixed, 95% CI) |
‐51.34 [‐76.38, ‐26.30] |
5.3 1000 mcg/day or greater |
0 |
0 |
Mean Difference (IV, Fixed, 95% CI) |
0.0 [0.0, 0.0] |
6 Change in evening PEFR (L/min) compared to baseline |
6 |
469 |
Mean Difference (IV, Fixed, 95% CI) |
‐20.64 [‐28.29, ‐13.00] |
6.1 400 mcg/day or less |
4 |
404 |
Mean Difference (IV, Fixed, 95% CI) |
‐16.03 [‐24.53, ‐7.54] |
6.2 500‐800 mcg/day |
2 |
65 |
Mean Difference (IV, Fixed, 95% CI) |
‐40.33 [‐57.88, ‐22.78] |
6.3 1000 mcg/day or greater |
0 |
0 |
Mean Difference (IV, Fixed, 95% CI) |
0.0 [0.0, 0.0] |
7 Change in daytime use of short‐acting beta2 agonist (puffs/daytime) compared to baseline |
5 |
480 |
Mean Difference (IV, Fixed, 95% CI) |
‐0.43 [‐0.80, ‐0.06] |
7.1 400 mcg/d or less |
5 |
480 |
Mean Difference (IV, Fixed, 95% CI) |
‐0.43 [‐0.80, ‐0.06] |
7.2 500‐800 mcg/day |
0 |
0 |
Mean Difference (IV, Fixed, 95% CI) |
0.0 [0.0, 0.0] |
7.3 1000 mcg/day or greater |
0 |
0 |
Mean Difference (IV, Fixed, 95% CI) |
0.0 [0.0, 0.0] |
8 Change in night‐time use of short‐acting beta2 agonist (puffs/night) compared to baseline |
3 |
304 |
Mean Difference (IV, Fixed, 95% CI) |
‐0.71 [‐1.09, ‐0.33] |
8.1 400 mcg/day or less |
3 |
304 |
Mean Difference (IV, Fixed, 95% CI) |
‐0.71 [‐1.09, ‐0.33] |
8.2 500‐800 mcg/day |
0 |
0 |
Mean Difference (IV, Fixed, 95% CI) |
0.0 [0.0, 0.0] |
8.3 1000 mcg/day or greater |
0 |
0 |
Mean Difference (IV, Fixed, 95% CI) |
0.0 [0.0, 0.0] |
9 Methacholine bronchial responsiveness (log 10 values) |
3 |
76 |
Mean Difference (IV, Fixed, 95% CI) |
‐0.04 [‐0.29, 0.21] |
9.1 400 mcg/day or less |
1 |
22 |
Mean Difference (IV, Fixed, 95% CI) |
0.04 [‐0.31, 0.39] |
9.2 500‐800 mcg/day |
2 |
54 |
Mean Difference (IV, Fixed, 95% CI) |
‐0.12 [‐0.48, 0.23] |
9.3 1000 mcg/day or greater |
0 |
0 |
Mean Difference (IV, Fixed, 95% CI) |
0.0 [0.0, 0.0] |
10 Histamine bronchial responsiveness (log 10 values) |
2 |
80 |
Mean Difference (IV, Fixed, 95% CI) |
‐0.40 [‐0.70, ‐0.11] |
10.1 400 mcg/day or less |
0 |
0 |
Mean Difference (IV, Fixed, 95% CI) |
0.0 [0.0, 0.0] |
10.2 500‐800 mcg/day |
2 |
80 |
Mean Difference (IV, Fixed, 95% CI) |
‐0.40 [‐0.70, ‐0.11] |
10.3 1000 mcg/day or greater |
0 |
0 |
Mean Difference (IV, Fixed, 95% CI) |
0.0 [0.0, 0.0] |
11 Withdrawal due to asthma exacerbation (No. of patients) |
17 |
910 |
Risk Ratio (M‐H, Fixed, 95% CI) |
0.17 [0.09, 0.33] |
11.1 400 mcg/day or less |
7 |
551 |
Risk Ratio (M‐H, Fixed, 95% CI) |
0.21 [0.08, 0.57] |
11.2 500‐800 mcg/day |
9 |
341 |
Risk Ratio (M‐H, Fixed, 95% CI) |
0.14 [0.05, 0.35] |
11.3 1000 mcg/day or greater |
1 |
18 |
Risk Ratio (M‐H, Fixed, 95% CI) |
0.33 [0.02, 7.24] |
12 Requirement for one or more courses of oral steroid for asthma exacerbation (No. of patients) |
5 |
255 |
Risk Ratio (M‐H, Fixed, 95% CI) |
0.34 [0.19, 0.59] |
12.1 400 mcg/day or less |
2 |
69 |
Risk Ratio (M‐H, Fixed, 95% CI) |
0.51 [0.18, 1.40] |
12.2 500‐800 mcg/day |
1 |
116 |
Risk Ratio (M‐H, Fixed, 95% CI) |
0.29 [0.14, 0.57] |
12.3 1000 mcg/day or greater |
2 |
70 |
Risk Ratio (M‐H, Fixed, 95% CI) |
0.33 [0.04, 2.94] |
13 Oropharyngeal side effects (No. of patients) |
5 |
275 |
Risk Ratio (M‐H, Fixed, 95% CI) |
0.81 [0.53, 1.23] |
13.1 400 mcg/day or less |
3 |
140 |
Risk Ratio (M‐H, Fixed, 95% CI) |
0.97 [0.51, 1.83] |
13.2 500‐800 mcg/day |
2 |
135 |
Risk Ratio (M‐H, Fixed, 95% CI) |
0.72 [0.41, 1.26] |
13.3 1000 mcg/day or greater |
0 |
0 |
Risk Ratio (M‐H, Fixed, 95% CI) |
0.0 [0.0, 0.0] |