Comparison 8. BUD v Placebo: crossover studies, not on oral steroids: all doses.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 FEV1 (% predicted)	3	56	Mean Difference (IV, Fixed, 95% CI)	‐4.55 [‐11.28, 2.19]
1.1 400 mcg/day or less	0	0	Mean Difference (IV, Fixed, 95% CI)	0.0 [0.0, 0.0]
1.2 500‐800 mcg/day	2	34	Mean Difference (IV, Fixed, 95% CI)	‐4.74 [‐12.59, 3.11]
1.3 1000 mcg/day or greater	1	22	Mean Difference (IV, Fixed, 95% CI)	‐4.0 [‐17.10, 9.10]
2 FEV1 (litres)	6	138	Mean Difference (IV, Fixed, 95% CI)	‐0.16 [‐0.40, 0.08]
2.1 400 mcg/day or less	0	0	Mean Difference (IV, Fixed, 95% CI)	0.0 [0.0, 0.0]
2.2 500‐800 mcg/day	1	24	Mean Difference (IV, Fixed, 95% CI)	‐0.08 [‐0.67, 0.51]
2.3 1000 mcg/day or greater	5	114	Mean Difference (IV, Fixed, 95% CI)	‐0.17 [‐0.44, 0.09]
3 Morning PEFR (L/min)	3	60	Mean Difference (IV, Fixed, 95% CI)	‐18.90 [‐66.94, 29.14]
3.1 400 mcg/day or less	0	0	Mean Difference (IV, Fixed, 95% CI)	0.0 [0.0, 0.0]
3.2 500‐800 mcg/day	0	0	Mean Difference (IV, Fixed, 95% CI)	0.0 [0.0, 0.0]
3.3 1000 mcg/day or greater	3	60	Mean Difference (IV, Fixed, 95% CI)	‐18.90 [‐66.94, 29.14]
4 Evening PEFR (L/min)	2	40	Mean Difference (IV, Fixed, 95% CI)	‐16.36 [‐45.93, 13.22]
4.1 400 mcg/day or less	0	0	Mean Difference (IV, Fixed, 95% CI)	0.0 [0.0, 0.0]
4.2 500‐800 mcg/day	0	0	Mean Difference (IV, Fixed, 95% CI)	0.0 [0.0, 0.0]
4.3 1000 mcg/day or greater	2	40	Mean Difference (IV, Fixed, 95% CI)	‐16.36 [‐45.93, 13.22]
5 Methacholine bronchial responsiveness (log 10 values)	4	84	Mean Difference (IV, Fixed, 95% CI)	‐0.40 [‐0.63, ‐0.18]
5.1 400 mcg/day or less	1	14	Mean Difference (IV, Fixed, 95% CI)	‐0.45 [‐1.12, 0.22]
5.2 500‐800 mcg/day	0	0	Mean Difference (IV, Fixed, 95% CI)	0.0 [0.0, 0.0]
5.3 1000 mcg/day or greater	3	70	Mean Difference (IV, Fixed, 95% CI)	‐0.40 [‐0.63, ‐0.16]