Comparison 12. BUD v Placebo: Crossover studies, not on oral steroids: all delivery devices.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 FEV1 (% predicted)	3	56	Mean Difference (IV, Fixed, 95% CI)	‐4.55 [‐11.28, 2.19]
1.1 MDI	0	0	Mean Difference (IV, Fixed, 95% CI)	0.0 [0.0, 0.0]
1.2 MDI+SPACER	0	0	Mean Difference (IV, Fixed, 95% CI)	0.0 [0.0, 0.0]
1.3 DPI	3	56	Mean Difference (IV, Fixed, 95% CI)	‐4.55 [‐11.28, 2.19]
2 FEV1 (litres)	6	138	Mean Difference (IV, Fixed, 95% CI)	‐0.16 [‐0.40, 0.08]
2.1 MDI	0	0	Mean Difference (IV, Fixed, 95% CI)	0.0 [0.0, 0.0]
2.2 MDI+SPACER	1	20	Mean Difference (IV, Fixed, 95% CI)	‐0.27 [‐0.90, 0.36]
2.3 DPI	5	118	Mean Difference (IV, Fixed, 95% CI)	‐0.14 [‐0.40, 0.12]
3 Morning PEFR (L/min)	3	60	Mean Difference (IV, Fixed, 95% CI)	‐18.90 [‐66.94, 29.14]
3.1 MDI	0	0	Mean Difference (IV, Fixed, 95% CI)	0.0 [0.0, 0.0]
3.2 MDI+SPACER	1	16	Mean Difference (IV, Fixed, 95% CI)	‐24.0 [‐132.48, 84.48]
3.3 DPI	2	44	Mean Difference (IV, Fixed, 95% CI)	‐17.66 [‐71.23, 35.92]
4 Evening PEFR (L/min)	2	40	Mean Difference (IV, Fixed, 95% CI)	‐16.36 [‐45.93, 13.22]
4.1 MDI	0	0	Mean Difference (IV, Fixed, 95% CI)	0.0 [0.0, 0.0]
4.2 MDI+SPACER	1	16	Mean Difference (IV, Fixed, 95% CI)	‐18.0 [‐51.81, 15.81]
4.3 DPI	1	24	Mean Difference (IV, Fixed, 95% CI)	‐11.0 [‐72.04, 50.04]
5 Methacholine bronchial responsiveness (log 10 values)	4	84	Mean Difference (IV, Fixed, 95% CI)	‐0.40 [‐0.63, ‐0.18]
5.1 MDI	0	0	Mean Difference (IV, Fixed, 95% CI)	0.0 [0.0, 0.0]
5.2 MDI+SPACER	0	0	Mean Difference (IV, Fixed, 95% CI)	0.0 [0.0, 0.0]
5.3 DPI	4	84	Mean Difference (IV, Fixed, 95% CI)	‐0.40 [‐0.63, ‐0.18]