Comparison 14. BUD v Placebo: Crossover studies, not on oral steroids: all study durations.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 FEV1 (% predicted)	3	56	Mean Difference (IV, Fixed, 95% CI)	‐4.55 [‐11.28, 2.19]
1.1 1‐4 weeks	3	56	Mean Difference (IV, Fixed, 95% CI)	‐4.55 [‐11.28, 2.19]
1.2 1‐5 months	0	0	Mean Difference (IV, Fixed, 95% CI)	0.0 [0.0, 0.0]
1.3 6 months or greater	0	0	Mean Difference (IV, Fixed, 95% CI)	0.0 [0.0, 0.0]
2 FEV1 (litres)	6	138	Mean Difference (IV, Fixed, 95% CI)	‐0.16 [‐0.40, 0.08]
2.1 1‐4 weeks	6	138	Mean Difference (IV, Fixed, 95% CI)	‐0.16 [‐0.40, 0.08]
2.2 1‐5 months	0	0	Mean Difference (IV, Fixed, 95% CI)	0.0 [0.0, 0.0]
2.3 6 months or greater	0	0	Mean Difference (IV, Fixed, 95% CI)	0.0 [0.0, 0.0]
3 Morning PEFR (L/min)	3	60	Mean Difference (IV, Fixed, 95% CI)	‐18.90 [‐66.94, 29.14]
3.1 1‐4 weeks	3	60	Mean Difference (IV, Fixed, 95% CI)	‐18.90 [‐66.94, 29.14]
3.2 1‐5 months	0	0	Mean Difference (IV, Fixed, 95% CI)	0.0 [0.0, 0.0]
3.3 6 months or greater	0	0	Mean Difference (IV, Fixed, 95% CI)	0.0 [0.0, 0.0]
4 Evening PEFR (L/min)	2	40	Mean Difference (IV, Fixed, 95% CI)	‐16.36 [‐45.93, 13.22]
4.1 1‐4 weeks	2	40	Mean Difference (IV, Fixed, 95% CI)	‐16.36 [‐45.93, 13.22]
4.2 1‐5 months	0	0	Mean Difference (IV, Fixed, 95% CI)	0.0 [0.0, 0.0]
4.3 6 months or greater	0	0	Mean Difference (IV, Fixed, 95% CI)	0.0 [0.0, 0.0]
5 Methacholine bronchial responsiveness (log 10 values)	4	84	Mean Difference (IV, Fixed, 95% CI)	‐0.40 [‐0.63, ‐0.18]
5.1 1‐4 weeks	4	84	Mean Difference (IV, Fixed, 95% CI)	‐0.40 [‐0.63, ‐0.18]
5.2 1‐5 months	0	0	Mean Difference (IV, Fixed, 95% CI)	0.0 [0.0, 0.0]
5.3 6 months or greater	0	0	Mean Difference (IV, Fixed, 95% CI)	0.0 [0.0, 0.0]