Agertoft 1997.
Methods | Setting: Denmark, paediatric outpatient clinic Randomisation: yes, computerised scheme prepared in balanced blocks Allocation concealment: unclear Design: crossover, 2 week washout Intervention period: 2 weeks Masking: double blind Excluded: none Withdrawals: stated Baseline characteristics: comparable Jadad score=4 | |
Participants | 48 children: 27M 21F Age range: 6 to 12 years Inclusion criteria: Clinical diagnosis of mild asthma requiring treatment with beta2 agonists only Exclusion criteria: Use of oral or inhaled steroids | |
Interventions | BUD:
1. 200 mcg/d
2. 400 mcg/d Placebo Delivery device: Turbohaler DPI |
|
Outcomes | Knemometry 24 urinary free cortisol excretion | |
Notes | This study also included treatment arms with fluticasone 200 mcg/d and 400 mcg/d: results not considered in this review. | |
Risk of bias | ||
Bias | Authors' judgement | Support for judgement |
Allocation concealment? | Unclear risk | B ‐ Unclear |