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. 1999 Oct 25;1999(4):CD003274. doi: 10.1002/14651858.CD003274

Baki 1998.

Methods Setting: Turkey, paediatric outpatient clinic 
 Length of intervention period: 3 weeks 
 Randomisation: yes, method not stated 
 Allocation concealment: unclear 
 Design: parallel 
 Masking: double blind 
 Excluded: not stated 
 Withdrawals: stated (none) 
 Baseline characteristics: comparable FEV1 and methacholine bronchial responsiveness but no other demographic data presented 
 Jadad score=3
Participants 43 children: 22M 21F 
 Age range: 7‐17 years 
 Inclusion criteria: 
 Diagnosis of mild to moderate asthma 
 Age 7‐17 years 
 FEV (% predicted) > 70 
 Methacholine BHR (PC20 FEV1) < 12 mg/ml 
 Exclusion criteria: 
 Respiratory tract infection within last 4 weeks
Interventions BUD: 200 mcg 2xdaily (400 mcg/d)
Placebo: 2xdaily, device not stated
Delivery device: not stated
Outcomes FEV1(% predicted) 
 Methacholine BHR (PC20 FEV1)
Notes No reply from author to clarify details of randomisation method or delivery device. 
 Individual patient methacholine challenge data was estimated from graph and log transformed. 
 Nedocromil and salmeterol treatment arms were also used: results not considered in this meta‐analysis
Risk of bias
Bias Authors' judgement Support for judgement
Allocation concealment? Unclear risk B ‐ Unclear