Bel 1991.
Methods | Setting: The Netherlands, hospital outpatient clinic Randomisation: yes, method not stated Allocation concealment: unclear Design: parallel Intervention period: 4 weeks Masking: double blind Excluded: not stated Withdrawals: stated Baseline characteristics: comparable Jadad score=3 | |
Participants | 16 patients: 8M 8F. Age range: 19‐34 years Inclusion criteria: History of episodic wheezing and dyspnoea, positive skin prick test to one or more airborne allergens. FEV1 (% predicted) > 80 and methacholine BHR (PC20 FEV1) 1‐7 mg/ml Symptoms controlled with bronchodilators only Exclusion criteria: Prior use of oral or inhaled corticosteroids | |
Interventions | BUD: 200 mcg 2pfs 2xdaily (800 mcg/d) Placebo: 2 pfs 2xdaily Delivery device: Turbuhaler DPI |
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Outcomes | FEV1 (% predicted) Methacholine BHR (PC20 FEV1) Withdrawal due to asthma exacerbation | |
Notes | Reply from author but unable to clarify details of randomisation method. Unclear whether methacholine challenge data log transformed prior to analysis. | |
Risk of bias | ||
Bias | Authors' judgement | Support for judgement |
Allocation concealment? | Unclear risk | B ‐ Unclear |