Bel 1991.

Methods	Setting: The Netherlands, hospital outpatient clinic Randomisation: yes, method not stated Allocation concealment: unclear Design: parallel Intervention period: 4 weeks Masking: double blind Excluded: not stated Withdrawals: stated Baseline characteristics: comparable Jadad score=3
Participants	16 patients: 8M 8F. Age range: 19‐34 years Inclusion criteria: History of episodic wheezing and dyspnoea, positive skin prick test to one or more airborne allergens. FEV1 (% predicted) > 80 and methacholine BHR (PC20 FEV1) 1‐7 mg/ml Symptoms controlled with bronchodilators only Exclusion criteria: Prior use of oral or inhaled corticosteroids
Interventions	BUD: 200 mcg 2pfs 2xdaily (800 mcg/d) Placebo: 2 pfs 2xdaily Delivery device: Turbuhaler DPI
Outcomes	FEV1 (% predicted) Methacholine BHR (PC20 FEV1) Withdrawal due to asthma exacerbation
Notes	Reply from author but unable to clarify details of randomisation method. Unclear whether methacholine challenge data log transformed prior to analysis.
Risk of bias
Bias	Authors' judgement	Support for judgement
Allocation concealment?	Unclear risk	B ‐ Unclear