Campbell 1991.

Methods	Setting: multicentre study UK, primary care. Randomisation: yes, computer‐generated randomisation schedule Allocation concealment: yes Design: parallel Intervention period: 8 weeks Masking: double blind Excluded: not stated Withdrawals: stated Baseline characteristics: comparable Jadad score=4
Participants	141 subjects: 74M 67F Inclusion criteria: Age > 12 years Reversibility of airway obstruction in response to inhaled beta2 agonists Inhaled bronchodilator at least once per day or experiencing asthma symptoms despite current treatment Exclusion criteria: Oral steroid use within previous month Current respiratory tract infection Pregnancy
Interventions	BUD: 200mcg 2 pfs 1xdaily (400 mcg/d) Placebo: 2 pfs 1xdaily Delivery device: Turbohaler DPI
Outcomes	Change in morning PEFR compared to baseline Change in evening PEFR compared to baseline Change in clinic PEFR compared to baseline Change in beta2 agonist use (puffs/d) compared to baseline % patients with improved: wheeze at rest and on activity; difficulty in breathing; cough; disturbed sleep; interference with usual routine (clinic assessment) % patients with improved: sleep disturbance; ease of falling asleep; no wheeze on waking; rested on waking; wheeze at rest; limitation of activity; hours active per day; satisfaction with lifestyle (diary card assessment) Withdrawal due to asthma exacerbation
Notes	Reply from author confirming details of randomisation method.
Risk of bias
Bias	Authors' judgement	Support for judgement
Allocation concealment?	Low risk	A ‐ Adequate