Fuller 1991.

Methods	Setting: UK, hospital outpatient clinic Randomisation: yes, method not stated Allocation concealment: unclear Design: crossover, 3 week washout Intervention period: 3 weeks Masking: double blind Excluded: not stated Withdrawals: stated Baseline characteristics: comparable Jadad score=3
Participants	10 subjects: 6M 4F Age range: 18‐45 years Inclusion criteria: Mild asthma requiring only irregular therapy with inhaled beta2 agonists Exclusion criteria: Not stated
Interventions	BUD: 600 mcg 2xdaily (1200 mcg/d) Placebo: twice daily Delivery device: MDI+spacer
Outcomes	FEV1 Morning PEFR Evening PEFR Bradykinin BHR (PD 35 Sgaw) Histamine BHR (PD 35 Sgaw)
Notes	No reply from author to clarify details of randomisation method.
Risk of bias
Bias	Authors' judgement	Support for judgement
Allocation concealment?	Unclear risk	B ‐ Unclear