Henriksen 1985.
Methods | Setting: Denmark, paediatric outpatient clinic Randomisation: yes, method not stated Allocation concealment: unclear Design: crossover, 2 week washout Intervention period: 3 weeks Masking: double blind Excluded: not stated Withdrawals: numbers given but reasons not stated Baseline characteristics: no demographic data presented Jadad score=2 | |
Participants | 16 children Age range: 8 to 15 years Inclusion criteria: Children with perennial asthma who demonstrated 20% or greater decrease in FEV1 following exercise challenge Exclusion criteria: Treatment with corticosteroids of any sort in previous 3 months | |
Interventions | BUD: 200mcg 1 pf 2xdaily (400 mcg/d) Placebo: 1 pf 2xdaily Delivery device: MDI+spacer |
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Outcomes | FEV1 (% predicted) Fall in FEV1 post exercise challenge as percentage of pre‐exercise baseline value 24 hour urinary free cortisol excretion Incidence of hoarseness | |
Notes | No reply from author to clarify details of randomisation method. | |
Risk of bias | ||
Bias | Authors' judgement | Support for judgement |
Allocation concealment? | Unclear risk | B ‐ Unclear |