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. 1999 Oct 25;1999(4):CD003274. doi: 10.1002/14651858.CD003274

Henriksen 1985.

Methods Setting: Denmark, paediatric outpatient clinic 
 Randomisation: yes, method not stated 
 Allocation concealment: unclear 
 Design: crossover, 2 week washout 
 Intervention period: 3 weeks 
 Masking: double blind 
 Excluded: not stated 
 Withdrawals: numbers given but reasons not stated 
 Baseline characteristics: no demographic data presented 
 Jadad score=2
Participants 16 children 
 Age range: 8 to 15 years 
 Inclusion criteria: 
 Children with perennial asthma who demonstrated 20% or greater decrease in FEV1 following exercise challenge 
 Exclusion criteria: 
 Treatment with corticosteroids of any sort in previous 3 months
Interventions BUD: 200mcg 1 pf 2xdaily (400 mcg/d)
Placebo: 1 pf 2xdaily
Delivery device: MDI+spacer
Outcomes FEV1 (% predicted) 
 Fall in FEV1 post exercise challenge as percentage of pre‐exercise baseline value 
 24 hour urinary free cortisol excretion 
 Incidence of hoarseness
Notes No reply from author to clarify details of randomisation method.
Risk of bias
Bias Authors' judgement Support for judgement
Allocation concealment? Unclear risk B ‐ Unclear