Kuo 1994.
Methods | Setting: Taiwan, hospital outpatient clinic Randomisation: yes, computer‐generated random number sequence Allocation concealment: unclear Design: parallel Intervention period: 4 weeks Masking: double blind Excluded: not stated Withdrawals: stated Baseline characteristics: comparable (those completing study) Jadad score=3 | |
Participants | 32 adults: 19M 13F Age range: 18‐64 years Inclusion criteria: Diagnosis of asthma (ATS criteria 1962) 15% or greater improvement in FEV1 after inhaled beta2 agonist Normal chest radiograph Exclusion criteria: Use of inhaled or oral steroids previous 6 weeks Current smokers or greater than 5 pack year smoking history Acute respiratory infection in last 2 weeks | |
Interventions | BUD: 800 mcg/d ) Placebo Delivery device: Turbuhaler DPI |
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Outcomes | FEV1 (% predicted) Methacholine BHR (PC20 FEV1) Daily PEFR Diurnal variability PEFR Blood hypodense eosinophil count Withdrawal due to asthma exacerbation | |
Notes | Reply from author: clarification of method of random order generation but unclear regarding allocation concealment. | |
Risk of bias | ||
Bias | Authors' judgement | Support for judgement |
Allocation concealment? | Unclear risk | B ‐ Unclear |