Kuo 1994.

Methods	Setting: Taiwan, hospital outpatient clinic Randomisation: yes, computer‐generated random number sequence Allocation concealment: unclear Design: parallel Intervention period: 4 weeks Masking: double blind Excluded: not stated Withdrawals: stated Baseline characteristics: comparable (those completing study) Jadad score=3
Participants	32 adults: 19M 13F Age range: 18‐64 years Inclusion criteria: Diagnosis of asthma (ATS criteria 1962) 15% or greater improvement in FEV1 after inhaled beta2 agonist Normal chest radiograph Exclusion criteria: Use of inhaled or oral steroids previous 6 weeks Current smokers or greater than 5 pack year smoking history Acute respiratory infection in last 2 weeks
Interventions	BUD: 800 mcg/d ) Placebo Delivery device: Turbuhaler DPI
Outcomes	FEV1 (% predicted) Methacholine BHR (PC20 FEV1) Daily PEFR Diurnal variability PEFR Blood hypodense eosinophil count Withdrawal due to asthma exacerbation
Notes	Reply from author: clarification of method of random order generation but unclear regarding allocation concealment.
Risk of bias
Bias	Authors' judgement	Support for judgement
Allocation concealment?	Unclear risk	B ‐ Unclear