O'Connor 1992.
Methods | Setting: UK, hospital outpatient clinic Randomisation: yes, computer‐generated randomisation sequence Allocation concealment: yes Design: crossover, 4 week washout Intervention period: 2 weeks Masking: double blind Excluded: not stated Withdrawals: stated (none) Baseline characteristics: comparable FEV1 (% predicted) Jadad score=4 | |
Participants | 12 adults: 6M 6F Age range: 20 to 46 years Inclusion criteria: Non smoking adult patients with mild asthma Positive allergen skin prick test to a common airborne allergen (Dermatophagoides pteronyssinus, mixed grass pollen, cat or dog fur) FEV1 (% predicted) > 80 Exclusion criteria: Exacerbation of asthma or respiratory infection in previous 6 weeks | |
Interventions | BUD: 400 mcg 2pfs 2xdaily (1600 mcg/d) Placebo: 2 pfs 2xdaily Delivery device: Turbuhaler DPI |
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Outcomes | FEV1 Methacholine BHR (PC20 FEV1) Sodium metabisulphite BHR (PC20 FEV1) Adenosine monophosphate BHR (PC20 FEV1) Blood eosinophil count | |
Notes | Reply from author clarifying method of random order generation and confirming use of allocation concealment. | |
Risk of bias | ||
Bias | Authors' judgement | Support for judgement |
Allocation concealment? | Low risk | A ‐ Adequate |