Rodriguez 1991.
Methods | Setting: Spain, hospital outpatient clinic Randomisation: yes, method not stated Allocation concealment: unclear Design: parallel Intervention period: 8 weeks Masking: not stated Excluded: not stated Withdrawals: none Baseline characteristics: no demographic data presented Jadad score=2 | |
Participants | 28 subjects: 13M 15F Age range: 14‐30 years Inclusion criteria: Diagnosis of asthma (ATS criteria 1962) FEV1 (%predicted) > 80 Positive methacholine bronchial challenge Normal paranasal sinus X‐ray | |
Interventions | BUD: 800 mcg/d for 4 weeks then 400 mcg/d for 4 weeks Placebo: 2 inhalations 2xdaily Delivery device: MDI |
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Outcomes | FEV1 (% predicted) FVC (% predicted) FEF50 Methacholine BHR (PD20 FEV1) Asthma symptom score Withdrawal due to asthma exacerbation | |
Notes | No reply from author to clarify details of randomisation method. | |
Risk of bias | ||
Bias | Authors' judgement | Support for judgement |
Allocation concealment? | Unclear risk | B ‐ Unclear |