Rodriguez 1991.

Methods	Setting: Spain, hospital outpatient clinic Randomisation: yes, method not stated Allocation concealment: unclear Design: parallel Intervention period: 8 weeks Masking: not stated Excluded: not stated Withdrawals: none Baseline characteristics: no demographic data presented Jadad score=2
Participants	28 subjects: 13M 15F Age range: 14‐30 years Inclusion criteria: Diagnosis of asthma (ATS criteria 1962) FEV1 (%predicted) > 80 Positive methacholine bronchial challenge Normal paranasal sinus X‐ray
Interventions	BUD: 800 mcg/d for 4 weeks then 400 mcg/d for 4 weeks Placebo: 2 inhalations 2xdaily Delivery device: MDI
Outcomes	FEV1 (% predicted) FVC (% predicted) FEF50 Methacholine BHR (PD20 FEV1) Asthma symptom score Withdrawal due to asthma exacerbation
Notes	No reply from author to clarify details of randomisation method.
Risk of bias
Bias	Authors' judgement	Support for judgement
Allocation concealment?	Unclear risk	B ‐ Unclear