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. 2021 Dec 13;9(12):e29286. doi: 10.2196/29286

Table 5.

Top 5 drugs interacting with statins during hospital consumption, along with the overall total for each security level.

Drug or statin Rosuvastatin, n (%) Simvastatin, n (%) Atorvastatin, n (%) Pravastatin, n (%) Fluvastatin, n (%)
Severity level: 1 (most severe)

Sodium fusidate (n=21) 3 (18.7) 0 (0) 14 (41.2) 4 (80) 0 (0)

Itraconazole (n=19) 0 (0) 2 (6.9) 17 (50) 0 (0) 0 (0)

Cyclosporin (n=15) 6 (37.5) 9 (31) 0 (0) 0 (0) 0 (0)

Erythromycin (n=12) 0 (0) 12 (41.4) 0 (0) 0 (0) 0 (0)

Fenofibrate (n=7) 7 (43.8) 0 (0) 0 (0) 0 (0) 0 (0)

Total 16 (100) 29 (100) 34 (100) 5 (100) 0 (0)
Severity level: 2

Rifampicin (n=118) 0 (0) 11 (40.7) 107 (56.9) 0 (0) 0 (0)

Fenofibrate (n=56) 7 (58.3) 3 (11.1) 36 (19.1) 8 (61.5) 2 (100)

Daptomycin (n=30) 5 (41.7) 3 (11.1) 19 (10.1) 3 (23.1) 0 (0)

Isoniazid (n=9) 0 (0) 0 (0) 9 (4.8) 0 (0) 0 (0)

Cyclosporin (n=8) 0 (0) 5 (18.5) 3 (1.6) 0 (0) 0 (0)

Total 12 (100) 27 (100) 188 (100) 13 (100) 2 (100)
Severity level: 3 (least severe)

Sodium polystyrene sulfonate (n=1142) 100 (19.7) 98 (9.4) 660 (18.7) 243 (20.2) 13 (16.5)

Warfarin sodium (n=894) 83 (16.3) 65 (6.2) 529 (14.9) 206 (17.1) 11 (13.9)

Fluindione (n=894) 92 (18.1) 88 (8.5) 504 (14.3) 196 (16.3) 14 (17.7)

Diosmectite (n=431) 42 (8.3) 31 (2.9) 259 (7.3) 93 (7.7) 6 (7.6)

Sodium bicarbonate or sodium alginatea (n=421) 39 (7.7) 39 (3.7) 242 (6.8) 93 (7.7) 8 (10.1)

Total 508 (100) 1040 (100) 3531 (100) 1204 (100) 79 (100)

aSodium bicarbonate-containing antacid.