Table 4.
Follow up changes in Anthropometric Characteristics, Biochemical Parameters and Serum Adipo-cytokines in individuals with obesity undergoing bariatric surgery (n=30) divided into IS and IR based on the HOMA-IR cut off.
| INSULIN RESISTANT OBESE (IR, n=22) |
INSULIN SENSITIVE OBESE (IS, n=8) |
|||||
|---|---|---|---|---|---|---|
| HOMA IR ≥ 2.5 |
HOMA IR < 2.5 |
|||||
| BASELINE (n=22) | POST-OP (n=22) | FOLLOW UP (n=14) | BASELINE (n=8) | POST-OP (n=8) | FOLLOW UP (n=4) | |
| Anthropometric Characteristics: | ||||||
| Body Weight (Kg) | 121.1 ± 6.50 | – | 90.69 ± 5.21*** | 117.7 ± 5.02 | – | 82.17 ± 5.44*** |
| BMI (Kg/m2) | 45.73 ± 1.45 | – | 34.08 ± 0.98*** | 47.16 ± 1.99 | – | 33.21 ± 2.01*** |
| Glucose Homeostasis: | ||||||
| Fasting Serum Glucose (mg/dL) | 96.93 ± 2.94 | – | 92.94 ± 3.45 | 112.5 ± 11.94 | – | 91.96 ± 9.06 |
| Fasting Serum Insulin (μU/L) | # #24.22 ± 2.77 | – | 9.31 ± 1.28*** | # #9.43 ± 2.66 | – | 4.67 ± 0.66 |
| HbA1c | 6.03 ± 0.14 | – | 5.56 ± 0.17** | 5.57 ± 0.25 | – | 5.63 ± 0.34 |
| HOMA-IR | # # #5.7 ± 0.61 | – | 2.15 ± 0.31*** | # # #1.18 ± 0.21 | – | 1.06 ± 0.17 |
| HOMA-B | # #324.4 ± 58.09 | – | 150.8 ± 31.90** | # #81.08 ± 34.11 | – | 88.28 ± 21.74 |
| QUICKI | # # #0.30 ± 0.01 | – | 0.35 ± 0.01*** | # # #0.36 ± 0.02 | – | 0.39 ± 0.01 |
| Serum Inflammatory Cytokines: | ||||||
| CRP (μg/ml) | 42.90 ± 22.76 | 55.05 ± 25.07 | #9.46 ± 3.06 | 33.88 ± 29.26 | 65.85 ± 54.5 | #12.17 ± 6.14 |
| TNF-α (pg/ml) | 30.47 ± 6.03 | 22.17 ± 4.61 | 35.53 ± 6.16 | 16.31 ± 4.88 | 17.12 ± 4.57 | 27.92 ± 6.52 |
| IL8 (pg/ml) | 131.4 ± 64.87 | 70.97 ± 27.04 | 91.13 ± 30.17 | 127.5 ± 71.79 | 124.0 ± 66.64 | 101.7 ± 18.35 |
| MCP1 (ng/ml) | 1.02 ± 0.08 | 0.99 ± 0.09 | 0.90 ± 0.15 | 0.87 ± 0.12 | 0.81 ± 0.11 | 0.82 ± 0.15 |
| IL6 (pg/ml) | 26.60 ± 5.14 | 40.92 ± 16.19 | 16.36 ± 6.64* | 14.54 ± 4.35 | 15.74 ± 3.12 | 5.94 ± 1.94 |
| Serum Adipocytokines: | ||||||
| Adiponectin (μg/ml) | 17.29 ± 1.50 | 17.09 ± 1.32 | 70.32 ± 14.25*** | 18.21 ± 2.88 | 20.13 ± 3.39 | 63.33 ± 33.49 |
| Resistin (ng/ml) | 44.75 ± 6.92 | 39.94 ± 6.78 | 27.14 ± 4.79* | 42.30 ± 10.22 | 50.51 ± 11.96 | 37.3 ± 11.39 |
Data is represented as Mean ± SEM. It was analysed using the paired Student's t-test for parametric variables and Wilcoxon Sign rank test for non-parametric variables.
* Comparison of post-op & follow up data with baseline within same sub-group i.e., IR or IS; *p <0.05, **p <0.01, ***p <0.001.
# Intergroup comparison of data at respective time points, e.g., follow up CRP of IR with that of IS. #p <0.05, ##p <0.01, ###p <0.001.