Table 3. East Quinoxaline Variations^a.

^aThe IC₅₀ values of the compounds of this work were determined with both the TNKS2 biochemical assay (quadruplicates used for each concentration tested, 95% confidence intervals are given in parentheses) and the cellular (HEK293) WNT/β-catenin signaling reporter assay (triplicates used for each concentration tested, T/F-tests were performed for the IC₅₀ curve fitting; all p > 0.95). * indicates shortlisted compound. ^# averages of multiple independent measurements; SEMs are shown in Table 5.