Figure 7.

Lowest energy conformers of Neurounina-1 and compounds 1–19 superimposed by the heavy atoms of the benzodiazepinone ring system. (A) Compounds with aliphatic R groups: Neurounina-1, compounds 1–3, 4–7, and 12–15. (B) Compounds with an aromatic R group: 8–11 and 16–19. Carbon atoms are colored according to the spacer group: Neurounina-1, compounds 1–3 (carbon atoms: green), 4–11 (carbon atoms: orange), and 12–19 (carbon atoms: magenta). The active analogues (Neurounina-1, compounds 1, 4, and 14) are displayed as ball and sticks; the inactive analogues are displayed as sticks. Heteroatoms are colored by atom type; hydrogen atoms are omitted for clarity of presentation except for those involved in hydrogen bonds. Hydrogen bonds are displayed as green dashed lines.