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. 2021 Nov 30;64(24):17901–17919. doi: 10.1021/acs.jmedchem.1c01212

Scheme 1. Reagents and Conditions: (a) Formaldehyde Solution 37% wt in H2O (10 equiv), Pyrrolidine (Compounds 1 and 2; 10 equiv) or Piperidine (Compound 3; 10 equiv), and Glacial Acetic Acid, MW (500 W, 15 min; T = 80 °C).

Scheme 1