Figure 5: Key matrix-associated growth factors (fibroblast growth factor (FGF2), hepatocyte growth factor (HGF), and transforming growth factor beta (TGFβ1)) do not bind to glycosaminoglycans (GAGs) isolated from decellularized non-COPD human lung extracellular matrix (ECM) homogenates.
Surface plasmon resonance analysis of the binding of 100 nM FGF2, HGF, and TGFβ1 was assessed in heparan sulfate (HS) and chondroitin sulfate/dermatan sulfate (CS/DS) isolated from 3 native and 3 decellularized non-COPD lung tissues. Representative graphs are shown from an individual lung. Heparin served as positive control for binding.