FIG. 3.

Potential immune-mediated mechanisms contributing to variability in blood pressure responses to salt. ENaC-mediated Na⁺ entry into the monocyte leads to IsoLG formation in APCs, which are presented as neoantigens to T cells and induce T cell activation. Activated T cells produce inflammatory cytokines, and infiltrate into kidney and vasculature, hence leading to salt sensitivity. Variability in the interstitial Na⁺ and monocyte Na⁺ sensing leading to variable IsoLG formation may account for the great variability seen in SSBP. Color images are available online.