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. 2021 Dec 13;125(50):13670–13684. doi: 10.1021/acs.jpcb.1c07602

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© 2021 The Authors. Published by American Chemical Society

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(a) Chemical structure of the deoxyribose sugar in DNA (left), LNA (center), and BNA (right) nucleotides. DNA shows the C2′-endo conformation found in the B-form DNA helix. LNA and BNA each show the ribose sugar locked into the C3′-endo conformation (found in the A-form helix) by a bridge connecting the 2′ oxygen to the 4′ carbon. (b) Sequences and chromophore locations for DNA-templated chromophore aggregates from zero (unlabeled) to four (tetramer) chromophores. Each design was reproduced with each of three scaffold variations: (1) DNA-only (DNA:DNA) (black), (2) seven LNA bases (DNA:LNA) (red), and (3) seven BNA bases (DNA:BNA) (blue). Inset (top right) shows the structure of the Cy5 chromophore and the phosphoramidite linkers to the DNA backbone.