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. 2021 Dec 27;219(2):e20211220. doi: 10.1084/jem.20211220

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© 2021 Fay et al.

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Figure 1. — Transmission of diverse microbial species to SPF mice during short-term cohousing. (A) Cohousing transmission model. (B) Serology analysis of pet store mouse infection history at the time of sacrifice. (C) Pet store mouse genotyping using the miniMUGA array, identifying a total of 4,431 high-quality markers (black hashes) on the autosomes and X chromosome segregating within the pet store mouse population. (D) Metagenomic classification and quantification of microbes in tissues from pet store, cohoused SPF, and control SPF mice. (E) DPCoA analysis of 16S rRNAseq from the small intestine contents of non-cohoused SPF, cohoused (CoH) SPF, and pet store mice. Data combined from B, n = 14 cages; C, n = 18 pet store mice; D, n = 12 cages; E, n = 6 cages. ds, double-stranded; ss, single-stranded.