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. 2021 Dec 15;13(12):1896–1918. doi: 10.4251/wjgo.v13.i12.1896

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©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.

This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/

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The place of combined therapy in the Barcelona clinic liver cancer classification algorithm. ¹Lesion not seen at ultrasound or in inappropiate positions; ²Lesion > 3 cm; ³Within Up-to-seven criteria. ABL: Ablation; HR: Hepatic resection; IOP: Intraoperatiove ablation; IT: Immunotherapy; LT: Liver transplantation; LRT: Locoregional therapy; OLT: Orthotopic liver transplantation; TACE: Transarterial chemoembolization; TARE: Transarterial radioembolization; TKI: Tyrosine kinase inhibitors.