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. Author manuscript; available in PMC: 2021 Dec 28.
Published in final edited form as: Bioconjug Chem. 2015 Oct 14;26(12):2435–2441. doi: 10.1021/acs.bioconjchem.5b00490

Figure 2.

Figure 2.

Agarose gel electrophoresis showing the difference in electrophoretic mobility between the conjugated- (2) and unconjugated-GS-AuNPs (1) under FL field (left) and bright field (right) (A). Zeta potential charge comparison among pure GS-AuNPs, insulin, and insulin-GS-AuNPs (B). Serum protein binding analyzed via agarose gel electrophoresis (C). Bioactivity of the NPs was assessed using normal balb/c mice, and compared with positive and negative controls (D). NPs were also i.v. injected into diabetic mice (NOD/ShiLtJ) and the BGL was monitored for 10 h p.i., including the preinjection (E).