Table 1.

Sensitivity and specificity of the cfDNA paired ctDNA methylation test and CEA in patients with tumor load and normal controls

Biopsy finding	ctDNA methylation test (n = 612)*					CEA test (n = 612) *
	n	Positive results (n)	Negative results (n)	Sensitivity %	Specificity %	n	Positive results (n)	Negative results (n)	Sensitivity %	Specificity %
Stage I	3	3	0	100.0		3	0	3	0.0
Stage II	32	21	11	65.6		32	9	23	28.1
Stage III	85	66	19	77.6		85	35	50	41.2
Stage IV	185	161	24	87.0		185	123	62	66.5
Total	305	251	54	82.3		305	167	138	54.8
Normal controls	307	14	293		95.4	307	9	298		97.1

^*Patients with tumor load were included in the sensitivity analysis