TABLE 2.
Frequency of Neurological and Nonneurological Manifestations by Overall and Acute SARS-CoV-2 and MIS-C Group
| Manifestations | Overall N = 1493 |
Acute SARS-CoV-2 N = 1278 (86%) | MIS-C N = 215 (14%) |
P Value |
|---|---|---|---|---|
| Headache | 309 (20.7) | 209 (16.4) | 100 (46.5) | <0.001 |
| Acute encephalopathy | 241 (16.1) | 193 (15.1) | 48 (22.3) | 0.008 |
| Clinical seizures/status epilepticus | 115 (7.7) | 108 (8.5) | 7 (3.3) | 0.005 |
| Weakness | 109 (7.3) | 89 (7.0) | 20 (9.3) | 0.223 |
| Dizziness | 95 (6.4) | 69 (5.4) | 26 (12.1) | <0.001 |
| Anosmia | 59 (4.0) | 51 (4.0) | 8 (3.7) | 0.851 |
| Ageusia | 54 (3.6) | 43 (3.4) | 11 (5.1) | 0.203 |
| Delirium | 43 (2.9) | 38 (3.0) | 5 (2.3) | 0.599 |
| Vision impairment | 37 (2.5) | 29 (2.3) | 8 (3.7) | 0.205 |
| Ataxia | 31 (2.1) | 28 (2.2) | 3 (1.4) | 0.449 |
| Numbness | 27 (1.8) | 26 (2.0) | 1 (0.5) | 0.110 |
| Syncope | 26 (1.7) | 23 (1.8) | 3 (1.4) | 0.675 |
| Coma | 25 (1.7) | 21 (1.6) | 4 (1.9) | 0.818 |
| Paresthesia | 23 (1.5) | 21 (1.6) | 2 (0.9) | 0.432 |
| Meningitis/encephalitis | 19 (1.3) | 15 (1.2) | 4 (1.9) | 0.406 |
| Sympathetic storming/dysautonomia | 21 (1.4) | 12 (0.9) | 9 (4.2) | <0.001 |
| Cardiac arrest | 16 (1.1) | 12 (0.9) | 4 (1.9) | 0.225 |
| Stroke | 13 (0.9) | 12 (0.9) | 1 (0.5) | 0.489 |
| Neuropathy | 12 (0.8) | 12 (0.9) | 0 (0.0) | 0.154 |
| Myelopathy | 6 (0.4) | 6 (0.5) | 0 (0.0) | 0.314 |
| Other reported neurological manifestations (free text) | ||||
| Coacute neurological condition∗ | 13 | 13 | 0 | |
| Acute psychosis | 7 | 4 | 3 | |
| Photophobia/phonophobia | 7 | 4 | 3 | |
| Abnormal motor movements | 6 | 6 | 0 | |
| Cranial nerve abnormality | 6 | 5 | 1 | |
| Hypotonia | 4 | 4 | 0 | |
| Papilledema | 2 | 1 | 1 | |
| Dysarthria | 2 | 2 | 0 | |
| Meningismus | 1 | 1 | 0 | |
| Arthralgia | 1 | 0 | 1 | |
| Dysphagia | 1 | 1 | 0 | |
| Moyamoya disease | 1 | 1 | 0 | |
| Unspecified | 1 | 1 | 0 |
Abbreviations:
MIS-C = Multisystem inflammatory syndrome in children
SARS-CoV-2 = Severe acute respiratory syndrome coronavirus 2
Results are reported as n (%).
∗
For example, traumatic brain injury.