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. Author manuscript; available in PMC: 2022 Feb 1.
Published in final edited form as: Toxicol Lett. 2021 Nov 17;355:41–46. doi: 10.1016/j.toxlet.2021.11.007

Fig. 1.

Fig. 1.

Mn phosphorylates YY1 at serine residues via AurkB and CK2 in H4 astrocytes. (A) Astrocytes were pre-treated with the AurkB inhibitor Hesperadin (Hesp, 250 nM, 1 h), then exposed to Mn(250 μM, 3 h) and immunoprecipitated with YY1 antibody, followed by western blotting for phosphoserine. (B) Astrocytes were pre-treated with the CK2 inhibitor CX-4945 (CX, 10 μM, 1 h), then exposed to Mn (250 μM, 3 h) and immunoprecipitated for YY1, followed by western blotting for phosphoserine. (**p < 0.01, ***p < 0.001, compared to the control; #p < 0.05, ##p < 0.01, ANOVA followed by Tukey’s post hoc test; N = 3).