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. Author manuscript; available in PMC: 2022 Sep 9.
Published in final edited form as: J Med Chem. 2021 Aug 18;64(17):12572–12581. doi: 10.1021/acs.jmedchem.1c00395

Figure 4.

Figure 4.

Cytotoxic activity of R4Fu-Q65R-MMAE and –DMSA in various cell lines. (A) Viability of HEK293T cells with or without over-expressing LGR4, LGR5, or LGR6. (B) Viability of LoVo cells with KO of LGR4 or KD of LGR5 treated with R4Fu-Q65R PDC. (C) Viability of LoVo cells treated with ADCs of LGR4, LGR5, or R4Fu-Q65R PDC. (D) Viability of PLC/PRF5 and AGS cells treated with R4Fu-Q65R-MMAE. Each experiment was repeated at least three times and shown here are representative graphs. Error bars are SD (N = 2).