Table 2.
Associations between neuroinflammatory and oxidative stress biomarkers and behavioral outcomes.
| Pearson’s r | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| GFAP | Iba-1 | Catalase | GSHR | GPx | SOD-1 | SOD-2 | GSHR Activity | GPx Activity | |
| Body Weight | 0.525 | 0.008 | 0.600 | 0.302 | 0.486 | −0.150 | 0.190 | 0.330 | −0.069 |
| CORT | 0.489 | 0.263 | −0.003 | −0.060 | 0.082 | −0.253 | 0.020 | 0.447 | 0.054 |
| Startle Change | −0.111 | 0.217 | 0.077 | −0.155 | 0.067 | −0.068 | 0.134 | 0.044 | −0.187 |
| Fear learning | −0.219 | 0.268 | −0.316 | −0.400 | −0.429 | 0.230 | −0.403 | 0.311 | −0.025 |
| Fear extinction | −0.252 | 0.297 | −0.305 | −0.149 | −0.371 | 0.080 | −0.260 | 0.190 | −0.093 |
| Anxiety Index | 0.388 | 0.184 | 0.207 | 0.045 | 0.332 | 0.250 | −0.026 | −0.028 | 0.104 |
| Stretch attends | 0.416 | 0.156 | 0.383 | 0.361 | 0.453 | 0.161 | −0.198 | −0.031 | −0.029 |
| Head dips | −0.692 | −0.110 | −0.048 | 0.035 | −0.223 | −0.473 | 0.025 | −0.141 | −0.364 |
| p Value | |||||||||
| GFAP | Iba-1 | Catalase | GSHR | GPx | SOD-1 | SOD-2 | GSHR Activity | GPx Activity | |
| Body Weight | 0.030 | 0.973 | 0.003 | 0.162 | 0.022 | 0.505 | 0.386 | 0.134 | 0.761 |
| CORT | 0.055 | 0.277 | 0.991 | 0.790 | 0.724 | 0.269 | 0.929 | 0.042 | 0.816 |
| Startle Change | 0.670 | 0.373 | 0.732 | 0.480 | 0.767 | 0.763 | 0.542 | 0.846 | 0.404 |
| Fear learning | 0.399 | 0.268 | 0.152 | 0.058 | 0.046 | 0.303 | 0.057 | 0.158 | 0.910 |
| Fear extinction | 0.330 | 0.217 | 0.168 | 0.498 | 0.090 | 0.722 | 0.232 | 0.398 | 0.679 |
| Anxiety Index | 0.124 | 0.450 | 0.356 | 0.838 | 0.131 | 0.263 | 0.906 | 0.902 | 0.645 |
| Stretch attends | 0.097 | 0.524 | 0.079 | 0.090 | 0.034 | 0.475 | 0.366 | 0.892 | 0.898 |
| Head dips | 0.004 | 0.676 | 0.840 | 0.879 | 0.344 | 0.035 | 0.916 | 0.554 | 0.105 |
| q Value | |||||||||
| GFAP | Iba-1 | Catalase | GSHR | GPx | SOD-1 | SOD-2 | GSHR Activity | GPx Activity | |
| Body Weight | 0.255 | 1.000 | 0.023 | 0.319 | 0.194 | 0.770 | 0.721 | 0.542 | 0.956 |
| CORT | 0.283 | 0.756 | 0.915 | 0.825 | 0.920 | 0.770 | 0.975 | 0.470 | 0.956 |
| Startle Change | 0.804 | 0.756 | 0.828 | 0.654 | 0.920 | 0.915 | 0.840 | 0.974 | 0.956 |
| Fear learning | 0.671 | 0.756 | 0.353 | 0.283 | 0.194 | 0.770 | 0.318 | 0.542 | 0.956 |
| Fear extinction | 0.615 | 0.756 | 0.353 | 0.654 | 0.251 | 0.915 | 0.649 | 0.836 | 0.956 |
| Anxiety Index | 0.347 | 0.756 | 0.582 | 0.825 | 0.315 | 0.770 | 0.975 | 0.974 | 0.956 |
| Stretch attends | 0.326 | 0.800 | 0.290 | 0.283 | 0.194 | 0.770 | 0.721 | 0.974 | 0.956 |
| Head dips | 0.107 | 0.597 | 0.980 | 0.844 | 0.597 | 0.313 | 0.597 | 0.915 | 0.554 |
| Sample Size | |||||||||
| GFAP | Iba-1 | Catalase | GSHR | GPx | SOD-1 | SOD-2 | GSHR Activity | GPx Activity | |
| Body Weight | 17 | 19 | 22 | 23 | 22 | 22 | 23 | 22 | 22 |
| CORT | 16 | 19 | 21 | 22 | 21 | 21 | 22 | 21 | 21 |
| Startle Change | 17 | 19 | 22 | 23 | 22 | 22 | 23 | 22 | 22 |
| Fear learning | 17 | 19 | 22 | 23 | 22 | 22 | 23 | 22 | 22 |
| Fear extinction | 17 | 19 | 22 | 23 | 22 | 22 | 23 | 22 | 22 |
| Anxiety Index | 17 | 19 | 22 | 23 | 22 | 22 | 23 | 22 | 22 |
| Stretch attends | 17 | 19 | 22 | 23 | 22 | 22 | 23 | 22 | 22 |
| Head dips | 15 | 17 | 20 | 21 | 20 | 20 | 21 | 20 | 21 |