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. Author manuscript; available in PMC: 2021 Dec 28.
Published in final edited form as: Sci Transl Med. 2018 Feb 28;10(430):eaao2731. doi: 10.1126/scitranslmed.aao2731

Fig. 7. CSPG4-high GBMs show more microglia than CSPG4-low GBMs and express TNFα.

Fig. 7.

(A) GBM expressing high amounts of CSPG4 (BT168) shows a high number of Iba1+ cells identified as microglia. (B) The only GBM negative for CSPG4 expression (BT274) in our cohort shows a total lack of Iba1+ cells. (C) Correlation of the percentage of CSPG4-positive tumor cells and Iba1-positive cells in the tumor mass (linear regression, P = 0.04). The cutoff for Iba1 expression was set at 10%. (D) Representative GBM specimen evaluated by immunofluorescence shows the presence of Iba1+ cells (green) coexpressing TNFα (merge). Two different areas are shown at two magnifications (scale bars, 25 μm). Nuclei are visualized by DAPI staining.