FIG. 8.

Long-term locomotor performance, weight, tissue sparing, and hemodynamics after NE treatment. One day after injury, rats were treated with NE or vehicle, and long-term recovery was assessed over 21 days (A). Animals injected with NE (0.5 mg/kg) 24 h after a SCI showed significantly lower BBB locomotor scores across the 21-day recovery period (B). No changes in weight loss were seen between groups (C). NE increased systolic BP immediately after treatment (D). Drug treatment had no effect on heart rate (E). NE induced an acute increase in blood flow (F). Histological analyses revealed that NE-treated rats showed greater lesion volume (G). Error bars represent standard error of the mean (SEM) (n = 8). Asterisks indicate significance differences between groups (*p < 0.05).