Table 1.
Number of Significant Differential Expression Events (Absolute Log2 Fold Change >1) and Differential Splicing Events (Absolute Difference Percent Spliced in >0.5) by Category of Steric-Blocking Oligonucleotide
| Analysis | Category | Q1 | Median | Q3 | No. of SBOs | No. of experiments | Median replicates |
|---|---|---|---|---|---|---|---|
| Expression | 3′ UTR | 565.5 | 823 | 1330.75 | 6 | 8 | 3 |
| Expression | Coding exonic | 63.75 | 397.5 | 1190.25 | 20 | 30 | 3 |
| Expression | Intronic | 29 | 137 | 750 | 7 | 9 | 3 |
| Expression | Nontargeting control | 6 | 9.5 | 53.75 | 3 | 4 | 3 |
| Expression | Promiscuous | 127 | 838 | 2263 | 3 | 6 | 3 |
| Expression | RBP motif | 8 | 239 | 1580 | 5 | 5 | 3 |
| Expression | Sense | 106.5 | 171 | 235.5 | 2 | 2 | 3 |
| Splicing | 3′ UTR | 5 | 10 | 52.75 | 6 | 8 | 3 |
| Splicing | 5′ UTR | 10.25 | 12.5 | 14.75 | 2 | 2 | 2 |
| Splicing | Coding exonic | 1 | 7 | 17 | 23 | 33 | 3 |
| Splicing | Intronic | 0 | 1 | 2 | 9 | 13 | 3 |
| Splicing | Nontargeting control | 0 | 0 | 0 | 3 | 5 | 3 |
| Splicing | Promiscuous | 2 | 6 | 21 | 31 | 37 | 2 |
| Splicing | RBP motif | 0 | 3 | 41 | 5 | 5 | 3 |
| Splicing | Sense | 0 | 0 | 0 | 2 | 2 | 3 |
SBOs, steric-blocking oligonucleotides.