Table 2.
Blood Pressure, Intraocular Pressure, and Ocular Perfusion Pressure at Baseline, with 1-Week Timolol Treatment, and with 1-Week Latanoprost Treatment in n = 121 Nonglaucomatous Volunteers
|
Baseline |
Timolol |
Latanoprost |
---|---|---|---|
Measure | Mean (SD); units: mmHg | ||
SBP | 124.4 (14.7) | 120.8 (13.7)a | 123.1(13.0) |
DBP | 77.1 (10.3) | 75.9 (10.5) | 77.6 (9.7) |
IOP | 15.8 (3.0) | 13.8 (2.5)a | 13.0 (2.1)a |
MOPP | 46.8 (8.1) | 48.5 (7.9)a | 49.6 (8.2)a |
SOPP | 108.5 (14.4) | 106.9 (13.7)a | 110.2 (13.1)a |
DOPP | 61.3 (10.8) | 62.0 (10.8)a | 64.7 (10.0)a |
MOPP = ⅔ [DBP + ⅓ (SBP − DBP)] − IOP. SOPP: (SBP − IOP). DOPP: (DBP − IOP).
Statistically significant difference (P < 0.05) from baseline in linear mixed-effect models.
DBP, diastolic blood pressure; DOPP, diastolic ocular perfusion pressure; IOP, intraocular pressure; MOPP, mean ocular perfusion pressure; SBP, systolic blood pressure; SOPP, systolic ocular perfusion pressure.