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. 2021 Dec 14;12:745945. doi: 10.3389/fimmu.2021.745945

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Copyright © 2021 Wu, Jiang, Liu, Lu, Lv and Liang

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Identification of CD8⁺ T cell related genes. (A) Kaplan-Meier analysis of CD8⁺ T cells. (B) Clustering dendrograms of immune-related differentially expressed genes (IRDEGs). Color intensity varies positively with abundance of CD8⁺ T cells. In terms of survival status, red means dead and white indicates live. (C, D) Analysis of scale-free fit index (C) and mean connectivity (D) for various soft-thresholding powers. (E) Clustering of module eigengenes. The red line shows cut height (0.25). (F) Dendrogram of robust IRDEGs clustered based on a dissimilarity measure (1-TOM). (G) Heatmap of the correlation between module eigengenes and clinical traits of ccRCC. Each cell contains p-value and the correlation coefficient. (H) Scatter plot of module eigengenes related to abundance of CD8⁺ T cells in the brown module.