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. 2021 Dec 14;12:745945. doi: 10.3389/fimmu.2021.745945

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Copyright © 2021 Wu, Jiang, Liu, Lu, Lv and Liang

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Exploration of extrinsic immune escape mechanisms among molecular clusters. Differences of immune score (A) and immune suppression score (B) between two molecular clusters. (C) Differences of the expression of TMEM173 (STING), IL10, IL10RA, TGFB3 and TGFBI between molecular clusters. (D) The relationship between molecular clusters and immune and non-immune cells in the tumor microenvironment. (E) The GZMB/CD8A ratio among molecular clusters. (F) A Sankey plot was used to reveal the correlation between molecular cluster and immune subtype. (****P < 0.0001; ***P < 0.001; *P < 0.05).