Table 1.

The IHI trigger tool medication module and the corresponding detectable ADEs

Original IHI trigger	Detectable ADE
M1: C. difficile-positive stool	Antibiotic AE
M2: PTT >100 sec	Bleeding on Heparin
M3: INR >6 a	Bleeding under VKA
M4: Glucose <50 mg/dl	Hypoglycemia
M5: Rising BUN or serum creatinine two times (2×) over baseline	Renal toxicity
M6: Vitamin K administration	Bleeding under VKA
M7: Diphenhydramine (benadryl) administration	Allergic reaction
M8: Romazicon (flumazenil) administration	Benzodiazepine AE
M9: Naloxone (narcan) administration	Opioid AE
M10: Anti-emetic administration	Medication-induced nausea
M11: Oversedation/hypotensionb	Overtreatment with hypnotic or antihypertensive agents
M12: Abrupt medication stop	ADE
M13: Other

Notes: ^aGerman Version IHI MMTT used INR >4. ^bUK Version IHI MMTT used systolic blood pressure <80 mmHg.

Abbreviations: BUN, blood urea nitrogen; VKA, vitamin K antagonist.