Table 3.
Adverse Events in Sorafenib and Lenvatinib Arms
| Lenvatinib Arm | Sorafenib Arm | P | |
|---|---|---|---|
| % | % | ||
| All toxicity | |||
| No | 2.8 | 2.1 | 1.00 |
| Yes | 97.2 | 97.9 | |
| GRADE | |||
| 1–2 | 67.8 | 72.3 | 0.43 |
| >2 | 29.4 | 25.6 | |
| HFSR | |||
| No | 89.5 | 61.8 | <0.000001 |
| Yes | 10.5 | 38.2 | |
| GRADE | |||
| 1–2 | 5.5 | 29.9 | 0.17 |
| >2 | 5.0 | 8.3 | |
| Diarrhea | |||
| No | 72.9 | 69.5 | 0.60 |
| Yes | 37.1 | 30.5 | |
| GRADE | |||
| 1–2 | 37.1 | 26.4 | 0.02 |
| >2 | 0.0 | 4.1 | |
| Hypertension | |||
| No | 64.6 | 75.7 | 0.053 |
| Yes | 35.4 | 24.3 | |
| GRADE | |||
| 1–2 | 9.0 | 19.4 | 0.000001 |
| >2 | 26.4 | 4.9 | |
| Fatigue | |||
| No | 59.0 | 70.8 | 0.04 |
| Yes | 41.0 | 29.2 | |
| GRADE | |||
| 1–2 | 25.0 | 24.3 | 0.01 |
| >2 | 16.0 | 4.9 | |
| Decrease appetite | |||
| No | 67.4 | NR | |
| Yes | 32.6 | NR | |
| GRADE | |||
| 1–2 | 20.1 | NR | |
| >2 | 12.5 | NR | |
| Proteinuria | |||
| No | 93.0 | NR | |
| Yes | 7.0 | NR | |
| GRADE | |||
| 1–2 | 4.2 | NR | |
| >2 | 2.8 | NR | |
| Hypothyroidism | |||
| No | 73.6 | NR | |
| Yes | 26.4 | NR | |
| GRADE | GRADE | ||
| 1–2 | 9.7 | NR | |
| >2 | 16.7 | NR | |
| Other toxicity | |||
| No | 68.7 | 54.9 | 0.01 |
| Yes | 31.3 | 45.1 | |
| GRADE | |||
| 1–2 | 17.4 | 38.9 | 0.001 |
| >2 | 13.9 | 6.2 |
Note: In bold font positive results.