Table 4.

Complication rate, mortality rate and hazard ratios in seronegative coeliac disease and conventional seropositive CD, stratified by center

COMPLICATIONS
	Patients, n	Incidence per 100 person-year (95% CI)	Hazard ratio (95% CI)	*p-value
All SNCD **	21	2.07 (1.28–3.16)	Vs SPCD 8.92 (5.22–15.25)	<0.001
True SNCD	17	2.48 (1.44–3.97)	Vs SPCD 10.87 (6.11–19.33)	<0.001
CD+IgAd	4	1.21 (0.33–3.10)	Vs SPCD 5.04 (1.79–14.20)	<0.01
			Vs SNCD 0.44 (0.15–1.32)	0.42
SPCD	37	0.24 (0.17–0.34)	1	-
MORTALITY
All SNCD **	14	1.27 (0.69–2.13)	Vs SPCD 2.22 (1.23–3.99)	<0.01
True SNCD	10	1.32 (0.63–2.42)	Vs SPCD 2.18 (1.12–4.26)	0.07
CD+IgAd	4	1.17 (0.32–2.99)	Vs SPCD 2.32 (0.82–6.56)	0.34
			Vs SNCD 1.14 (0.33–3.92)	1.00
SPCD	82	0.54 (0.43–0.67)	1	-

SNCD: seronegative coeliac disease; SPCD: seropositive coeliac disease; CD+IgAd: coeliac disease associated to IgA deficiency; vs.:versus;

^*post-hoc comparison p values adjusted according to Bonferroni

^**this group included patients with true seronegative coeliac disease and coeliac disease associated to IgA deficiency together