Table 5.

Multivariable Cox models for development of complications and mortality stratified by centre

COMPLICATIONS
Factor	Hazard ratio (95% CI)	*p-value
Age at diagnosis (years)	1.04 (1.02–1.06)	<0.001
True SNCD	7.78 (4.23–14.31)	<0.001
CD+IgAd	5.25 (1.80–15.34)	<0.01
SPCD	1	-
Male	1.39 (0.80–2.42)	0.25
Female	1	-
Classical presentation	1	-
Non-classical presentation	0.32 (0.16–0.63)	<0.01
Silent presentation	0.16 (0.04–0.69)	0.01
Clinical response to a GFD	0.12 (0.06–0.25)	<0.001
MORTALITY
Age at diagnosis (years)	1.10 (1.08–1.12)	<0.001
True SNCD	1.04 (0.48–2.26)	0.93
CD+IgAd	1.38 (0.46–4.12)	0.56
SPCD	1	-
Male	1.48 (0.97–2.27)	0.07
Female	1	-
Classical presentation	1	-
Non-classical presentation	0.98 (0.61–1.57)	0.94
Silent presentation	1.04 (0.51–2.15)	0.91
Clinical response to a GFD	0.51 (0.32–0.81)	<0.01
Development of complications	3.80 (2.10–6.86)	<0.001

SNCD: seronegative coeliac disease; SPCD: seropositive coeliac disease; CD+IgAd: coeliac disease associated to IgA deficiency; vs.:versus;

^**this group included patients with true seronegative coeliac disease and coeliac disease associated to IgA deficiency together