Fig. 1.

Schematic overview of our hypothesis for how Tri-CAP leads to blockade of three cancer survival pathways for overcoming therapy resistance. (A) Tri-CAP generates exceptionally low levels of ROS, charges and atoms, photons, and transient electric fields in ambient air. (B) This leads to formation of diverse, low-level, aqueous ROS and charges in the cell medium. (C) Tri-CAP–induced pulsed elevation of diverse intracellular ROS simultaneously disrupts three key cancer survival pathways—deregulated redox balance, glycolysis, and sustained proliferative signaling—in therapy-resistant cancer cells. RNS, reactive nitrogen species; G6P, glucose-6-phosphate; PEP, phosphoenolpyruvate.