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ORP5 and/or ORP8 KD inhibits tumor growth of KRAS-mutant PDAC in vivo. Monoclonal shORP5, shORP8, and shORP5/8 KD MiaPaCa-2 and BxPC-3 cells were injected subcutaneously in the left flanks of nu/nu-immunosuppressed mice. Monoclonal empty vector controls (CN) were injected in the right flanks to serve as internal controls. Tumors were harvested after 6 to 8 wk (one-way ANOVA, ***P < 0.005; n = 8 per group). ns, nonsignificant.
