Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2021 Dec 15;118(51):e2112625118. doi: 10.1073/pnas.2112625118

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Published under the PNAS license.

PMC Copyright notice

Fig. 4. — Loss of MEKK3 in ECs impairs blood-flow recovery and increases TGFβ-signaling in hindlimb ischemia (HLI) model. (A) Representative images of blood-flow recovery from Ctrl and Mekk3^iECKO mice at indicated days. (B) Quantification of blood-flow recovery for Ctrl and Mekk3^iECKO mice. Data represent mean ± SD. n = 6 male mice per group. (C and D) Immunostaining of eNOS and SMA (C) and TGFβ and p-Smad3 (D) in gracilis muscle blood vessels from Ctrl and Mekk3^iECKO mice at day 7. (Scale bar, 20 μm.) (E and F) SMA immunostaining and quantification of blood vessels diameter for Ctrl and Mekk3^iECKO mice. Data represent mean ± SEM. n = 6 male mice per group. (Scale bar, 50 μm.) **P < 0.01, ***P < 0.001, and ns: not significant, calculated by unpaired t test (F) and two-way ANOVA with Sidak’s multiple comparison tests (B).